Post‐translational modifications regulate each step of DNA replication to ensure the faithful transmission of genetic information. In this context, we recently showed that deubiquitination of SUMO2/3 and SUMOylated proteins by USP7 helps to create a SUMO‐rich and ubiquitin‐low environment around replisomes that is necessary to maintain the activity of replication forks and for new origin firing. We propose that a two‐flag system mediates the collective concentration of factors at sites of DNA replication, whereby SUMO and Ubiquitinated‐SUMO would constitute “stay” or (...) “go” signals respectively for replisome and accessory factors. We here discuss the findings that led to this model, which have implications for the potential use of USP7 inhibitors as anticancer agents. (shrink)

AimThe functional prognosis of patients after coma following either cardiac arrest or acute structural brain injury is often uncertain. These patients are associated with high mortality and disability. N20 and N70 somatosensory evoked potentials are used to predict prognosis. We evaluated the utility of SSEP as an early indicator of long-term prognosis in these patients.MethodsThis was a retrospective cohort study of patients admitted to the intensive care unit with a diagnosis of coma after CA or ABI. An SSEP study was (...) performed, including N20 and N70 at 24–72 h, after coma onset. Functional recovery was assessed 6–12 months later using the modified Glasgow scale. The study was approved by our local research ethics committee.ResultsIn the CA and ABI groups, the absence of N20 or N70 was a strong indicator of poor outcome. Conversely, the presence of N70 was an indicator of a good outcome.ConclusionSomatosensory evoked potentials are useful early prognostic markers with high specificity and sensitivity. Moreover, N70 has additional potential value for improving the prediction of good long-term functional outcomes.Clinical Trial Registration:[https://clinicaltrials.gov/], identifier [2018/01/001]. (shrink)

The axiom Extra Ecclesiam nulla salus was drawn up by Cyprian of Carthage in the middle of the third century. In the Middle Ages it was essential for the pontifical theocracy with popes like Gregory VII (Dictatus papae, 1075) Inocent III (IV Lateran Council, 1215) and Boniface VIII (Bull Unam Sanctam , 1302).With the necessary adaptations and nuances (St. ThomasAquinas in the XIIIth century; the theologians of Salamanca in the XVIth century, the II Vatican Council in the XXth century) the (...) controversy around this maxim has reached our days. (shrink)

A lo largo de la Edad Media se fijó en siete el número de sacramentos. Dos de ellos serán reconocidos como «sociales» por establecer las formas e ideales de vida de dos categorías humanas. A una minoría reconocida como guía moral –el orden sacerdotal– se le pide un compromiso con el celibato. A la masa de fieles –el laicado– se le proponía el estado conyugal según normas –las del matrimonio cristiano– que le distinguían de otras formas de relación carnal. En (...) ambos casos, sin embargo, lo real y lo ideal frecuentemente difieren. (shrink)

Las polémicas entre mentira (importante vitium linguae según los moralistas) y verdad (identificada con una idea superior, incluso con la divinidad) han sido muy características de la Europa cristiana medieval. Sobre bases bíblicas, patrísticas, escolásticas y prerrenacentistas, las disputas han afectado tanto a los medios académicos (vg. la teoría de la Duplex veritas atribuida a los averroístas) como al común de los cristianos (vg. El recurso a la ordalía).

Rationale, aims and objectives Given the increasing prevalence of cataract and demand for cataract extraction surgery, patients must often wait to undergo this procedure. We validated a previously developed priority scoring system in terms of clinical variables, pre-intervention health status, appropriateness of surgery and gain in visual acuity (VA) and health-related quality of life (HRQoL).Methods Explicit prioritization criteria for cataract extraction created by a variation of the Research and Development (RAND) and University of California Los Angeles appropriateness methodology were retrospectively (...) applied to a prospective cohort of 5257 patients on waiting lists to undergo cataract by phacoemulsification at 17 hospitals in Spain. Demographic data, clinical data and data related to surgical technique were collected by trained ophthalmologists. Patients were evaluated by their ophthalmologist before the intervention and 6 weeks afterward. They also completed, by mail, the Visual Function Index (VF-14) before the intervention and 3 months afterward.Results High-priority patients experienced greater improvement in VA and HRQoL than those classified as intermediate or low-priority (P < 0.0001), even after adjusting by VA and the VF-14 score at baseline. The time to intervention was the same for high-priority patients as it was for intermediate and low-priority patients.Conclusions The priority score we developed identified patients most likely to experience the greatest improvements from cataract extraction. Use of this tool could provide a fairer and more rational way to prioritize patients for cataract extraction. (shrink)

La introducción al ensayo relaciona la escritura y la supervivencia en Unamuno y en Lledó -en el primero como voluntad multidimensional y en el segundo como memoria viva colectiva- y después compendia la vida y la obra de Emilio Lledó El ensayo comenta varios textos de la obra de Lledó Memoria de la ética acerca de la muerte y de la existencia extendida en la época clásica de la cultura y la filosofía griegas. Como conclusión, y a partir del (...) epicureísmo de Lledó, se reafirma una cierta distinción entre las propuestas de una teoría de la vida post-mortem basada en la pervivencia por la memoria y otra que apunta a la vida perdurable por el impulso del ánimo o thymós. (shrink)

El que en el presente libro se confronten "lenguaje" e "historia" pretende indicar que una parte especial de los que hemos sido se hace presente como "lenguaje"; pero, además, según se analiza en sus páginas, la función del historiador tuvo, en principio, algo elemental y simple. La misma etimología de la palabra significa alguien a quien se le pide consejo sobre un hecho porque "él vio lo que pasó". Al decir lo que ve, lo que interpreta, el historiador compromete la (...) veracidad de su propio ser. Colección Clásicos - Dykinson (títulos publicados)?Serie estudios?? - Sobre la democracia ateniense. Luis Gil Fernández. - Derecho natural y dignidad humana. Ernst Bloch. - Alejo Carpentier. Poética del Mediterráneo Caribe. Inmaculada López Calahorro. - P. Szondi. Teoría del drama moderno. Ensayo sobre lo trágico. - El concepto poíesis en la filosofía griega. Emilio Lledó. - Lenguaje e historia. Emilio Lledó.?Serie textos? - Heródoto. Historia. Libro I. Ed. bilingüe de J. M. Floristán. - Sófocles. Electra. Ed. bilingüe de Luis Gil Fernández. - Platón. Fedro. Ed. bilingüe de Luis Gil Fernández. - Aristóteles. Poética. Ed. bilingüe de Paloma Ortiz García. - Horacio. Arte poética. Ed. bilingüe de Luis Gil Fernández. - Boileau. El arte poética y otras sátiras. Ed. bilingüe de Alberto Torrego Salcedo. - Lezama Lima. Escritos de Estética. Ed. de Pedro Aullón de Haro. - República poética. Textos programáticos de la literatura española (siglos XVIII y XIX). Ed. de Germán Garrido Miñambres. (shrink)

[español] En primer lugar, el texto ofrece un acercamiento al papel que amor y nostalgia cumplen en la poesía de Emilio Prados, así como a su íntimo nexo con la muerte como aniquilación mística. Como herramienta interpetativa, recurriré a la razón poética de María Zambrano, autora profundamente emparentada, vital y teóricamente, con la poesía pradiana. Este enfoque permitirá una visión de conjunto sobre la obra del poeta español y en segundo lugar, trazar una comparativa con el saudosismo de Teixeira (...) de Pascoaes. Así, indicaré las numerosas coincidencias que existen entre ambos y me detendré en la cuestión de la muerte mística, ámbito más problemático, donde sin embargo, puede apreciarse una comunión de espíritu entre el español y el portugués. ****************** [english] Firstly, the text offers an approach to the function of love and nostalgia in the poetry of Emilio Prados, as much as its intimate connection with death as mystical annihilation. As interpretive tool, I will use the poetic reason of María Zambrano, an author deeply linked, vital and theoretically, with pradian poetry. This focus will provide an overall view of Prado's work and the possibility of a comparison with Teixeira de Pascoaes's saudosism. Thus, I will point same coincidences between them and I will consider the question of mystical death. This sphere, although it is problematic, can show some kind of community of spirit between both. (shrink)

Resumen: En la historia de la recepción de Samuel Beckett en los países de habla no inglesa, la primera traducción de Comment c’est al castellano, realizada por José Emilio Pacheco en 1966, aparece como un hito aislado y deslumbrante. Esta traducción a partir del texto original en francés, hecha por el poeta mexicano cuando tenía 27 años, no tuvo una repercusión notable en su momento, a pesar de la audacia de la empresa y de la brillantez de la traducción. (...) Sin embargo, a raíz de la trayectoria de Pacheco como crítico, traductor y poeta de primera magnitud, se considera necesario hacer una evaluación en profundidad de este texto único. El objetivo de este artículo es el de analizar la versión de Pacheco del texto beckettiano por medio de un acercamiento al contexto histórico y a los elementos propios de su bagaje cultural que el poeta aporta a la elaboración de su traducción. Se trata, en definitiva, de explicar cómo se lee a Beckett en español por medio de Pacheco.: The first translation into Spanish of Samuel Beckett’s Comment c’est, by José Emilio Pacheco, Cómo es, stands out as a dazzling and unprecedented landmark in the history of the reception of the Irish author in non-English-speaking countries. In his translation the 27-year-old Mexican poet took the French original version as his main source but, despite its daring quality and the brilliance of the text rendered into Spanish, it had little impact in the cultural atmosphere of its day. In light of Pacheco’s standing in the world of letters as a first-rank critic, translator and poet, it is deemed necessary a reassessment of this unique text. The aim of this article is to analyze Pacheco’s translation of Samuel Beckett’s novel; for this purpose, the historical context and the personal elements that the poet incorporated from his personal background into his version of Comment c’est will be studied in detail. All in all, the final objective of this research is to explain how Beckett is read in Spanish through Pacheco’s version. (shrink)

Memories are mental states with a number of interesting features. One of those features seems to be their having an intentional object. After all, we commonly say that memories are about things, and that a subject represents the world in a certain way by virtue of remembering something. It is unclear, however, what sorts of entities constitute the intentional objects of memory. In particular, it is not clear whether those are mind-independent entities in the world or whether they are mental (...) entities of some kind. The purpose of this chapter is to map the different positions on this issue, and to highlight the virtues and difficulties for each of the options. In Section 2, I will specify the question of what the intentional objects of memory are by clarifying the relevant notions of memory and intentional object. In Section 3, I will motivate the significance of identifying the intentional objects of memory by exploring the relations between, on the one hand, the intentionality of memory and, on the other hand, the phenomenology and the epistemology of memory. In Section 4, I will consider two natural candidates for being the intentional objects of memory, namely, worldly entities and mental entities, and I will raise some concerns for each of the two candidates. A promising alternative will emerge, in Section 5, as preserving the virtues of the two original candidates while avoiding their difficulties. The alternative will concern a certain combination of worldly and mental entities; a combination that involves both causal and truth-making relations. I will conclude by sketching how the alternative candidate can shed some light on the phenomenological and epistemological issues raised in the third section. (shrink)

Our memories elicit, in us, both beliefs about what the external world was like in the past, and beliefs about what our own past experience of it was like in the past. What explains the power of memories to do that? I tackle this question by offering an account of the content of our memories. According to this account, our memories are ‘token-reflexives’, in that they represent their own causal origin. My main contention will be that our memories are able (...) to provide us with evidence for the two types of beliefs due to the self-referential nature of their content. First, I will put forward a series of thought-experiments intended to raise several intuitions about the veridicality of memories. Next, I will introduce the view that memories are token-reflexives, and I will motivate it by pointing out that the view accommodates the relevant intuitions. And, then, I will return to the two types of beliefs prompted by our memories, and argue that conceiving memories as token-reflexives allows us to explain why memory has the power to elicit the two types of beliefs in us. (shrink)

Hailed by the Journal of the History of Astronomy as "charming and witty," this chronicle by a renowned physicist traces the development of scientific thought from the works of the "founding fathers" — Galileo, Huygens, and Newton — to the more recent discoveries of Maxwell, Boltzmann, and Gibbs. 1984 edition.

Le présent ouvrage comble une lacune. La recherche, en effet, n'avait jamais pris en vue de manière systématique et détaillée l'ensemble de la philosophie schellingienne dans son rapport à la théologie. (C'est d'autant plus surprenant si l'on se rappelle que la pensée de Schelling représente le dernier essai de grand style d'établir une médiation entre ces deux disciplines.) En pratiquant sur toute l'œuvre une coupe longitudinale - depuis les premiers écrits critiques sur le mal et le mythe, à travers la (...) spéculation théogonique des Ages du monde, jusqu'aux développements christologiques et ecclésiologiques de la dernière période - le livre retrace le devenir de la théologie de Schelling, s'intégrant dans sa pensée comme l'une de ses composantes. Cette méthode permet de mettre en évidence la façon dont le philosophe théologien s'est critiqué lui-même dans les diverses phases de sa longue carrière et a modifié ses positions initiales pour tenter d'échapper à la synthèse idéaliste de la foi et du savoir, sans parvenir toutefois à se dégager entièrement du schéma de l'identité. (shrink)

One of the most influential works of this century, The Myth of Sisyphus and Other Essays is a crucial exposition of existentialist thought. Influenced by works such as Don Juan and the novels of Kafka, these essays begin with a meditation on suicide; the question of living or not living in a universe devoid of order or meaning. With lyric eloquence, Albert Camus brilliantly posits a way out of despair, reaffirming the value of personal existence, and the possibility of (...) life lived with dignity and authenticity. (shrink)

En este trabajo se analiza la tesis foucaultiana de la reducción de la filosofía a forma de conocimiento en Descartes y el consecuente abandono de la espiritualidad clásica, es decir, de la filosofía concebida como forma de vida basada en el cuidado de sí. A partir de aquí, además de observar que el propio Foucault matizará esta tesis, se demostrará que en Descartes la filosofía sigue esencialmente unida a la espiritualidad.

Grace a son interrogation incomparablement tenace et incisive sur le sens de l'etre, la pensee heideggerienne accede a une comprehension du sacre qui semble irreductible a tout autre, et qui, par son originalite et sa profondeur, compte parmi les plus significatives elaborees a notre epoque. Le present ouvrage etudie le rapport complexe entre cette notion du sacre et les eclaircissements heideggeriens sur le divin et la mediation poetique. Il s'articule en quatre parties, dont la premiere expose la genese de l'interpretation (...) heideggerienne du sacre. La deuxieme partie propose une etude thematique du nouveau lexique que Heidegger, au contact notamment de la poesie de Holderlin, introduit dans sa meditation du sacre. La troisieme partie entreprend une serie de discernements critiques, en se laissant instruire par les principaux travaux qui ont examine explicitement la comprehension heideggerienne du sacre, du divin, et du poete. Dans une perspective synthetique, la quatrieme partie, enfin, s'efforce de ressaisir l'approche de Heidegger par le biais de ce qui la deborde, en la faisant dialoguer avec d'autres pensees philosophiques et theologiques marquantes; ce qui conduit a considerer, entre autres, la difference du sacre et du Saint. Degage a partir des developpements diachroniques de la premiere partie, le triptyque du sacre, du divin, et du poete structure aussi bien les synchronisations thematiques de la deuxieme partie que les discernements critiques fournis par la troisieme, et il est assume, tout en etant "depasse", par les chapitres systematiques de la derniere partie. (shrink)

Translated by Anthony Bower With an Introduction by Oliver Todd 'A conscience with style' V.S. Pritchett The Rebel (1951) is Camus's 'attempt to understand the time I live in' and a brilliant essay on the nature of human revolt. Here he makes a daring critique of communism - how it had gone wrong behind the Iron Curtain and the resulting totalitarian regimes. And he questions two events held sacred by the left wing - the French Revolution of 1789 and (...) the Russian Revolution of 1917 - that had resulted, he believed, in the use of terrorism as a political instrument. In this towering intellectual document, Camus argues that hope for the future lies in revolt with revolution - a chance to achieve change without losing our freedom. 'The last French intellectual to take the side of humanity and talk its language... a figure of immense moral stature' Sunday Times Winner of the Nobel Prize for Literature. (shrink)

We present a preliminary high-level formal theory, grounded on knowledge representation techniques and foundational ontologies, for the uniform and integrated representation of the different kinds of (quali- tative and quantitative) knowledge involved in the designing process. We discuss the conceptual nature of engineering design by individuating and analyzing the involved notions. These notions are then formally charac- terized by extending the DOLCE foundational ontology. Our ultimate purpose is twofold: (i) to contribute to foundational issues of design; and (ii) to support (...) the development of advanced modelling systems for (qualitative and quantitative) representation of design knowledge. (shrink)

Se analizará una aporía inherente al giro subjetivo del último Foucault causada por el sostenimiento simultáneo de dos sentidos incompatibles de la irreductibilidad del sujeto y, por lo tanto, de su posible emancipación: en unos casos es posible hacer referencia a procesos de subjetivación externos a las formas de subjetividad generadas por el poder ; pero, en otros, los procesos de emancipación no pueden ser pensados más allá de la resistencia al poder. La hipótesis del trabajo es que la aporía (...) está producida por la gradual marginación del problema del autoconocimiento en la temática del cuidado de sí, que, como resultado, pasa a ser comprendida exclusivamente desde las prácticas cínicas. Pero reducido el autoconocimiento, también es eliminada la problemática del cuidado de sí, que sostenía la noción fuerte de la subjetividad. Se mostrará que en el Barroco literario y neoestoico español se pueden encontrar elementos para recuperarla. (shrink)